RAI stage

What is RAI stage?

RAI stage meaning Chronic lymphocytic leukemia (CLL) has no standard staging system; however, a National Cancer Institute (NCI)-sponsored work group formulated standardized guidelines for criteria eligibility, response, and toxic effects to be used in future clinical trials in CLL.The RAI staging system has 5 stage groups. Stage 0Stage 0 CLL is characterized by absolute lymphocytosis (>15,000/mm3) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia.Stage IStage I CLL is characterized by absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia.Stage IIStage II CLL is characterized by absolute lymphocytosis with either hepatomegaly or splenomegaly with or without lymphadenopathy.Stage IIIStage III CLL is characterized by absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly.Stage IVStage IV CLL is characterized by absolute lymphocytosis and thrombocytopenia (<100,000/mm3) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.

 

reference: national Cancer Institute – Glossary for Registrars

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