Monoclonal protein

What is Monoclonal protein?

Monoclonal protein meaning An antibody made by myeloma cells that is synthesized uncontrollably, as opposed to being synthesizedin response to a germ. M-proteins are found in excessive amounts in the blood or urine of patients withmultiple myeloma. They have an abnormal amino acid sequence and protein structure owing to mutationsin the genes responsible for immunoglobulin production in the myeloma cells that make them. Unlikenormal antibodies, M-proteins are unable to fight infections. The identification of an M-protein is important for diagnosis, and the level of M-protein can help measure treatment effectiveness.


reference: national Cancer Institute – Glossary for Registrars

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