Hemolytic anemia

What is Hemolytic anemia?

Hemolytic anemia meaning Hemolytic anemia is a disorder in which the red blood cells are destroyed faster than the bone marrow can produce them. The term for destruction of red blood cells is hemolysis. There are two types of hemolytic anemia, intrinsic and extrinsic:Intrinsic: The destruction of the red blood cells is due to a defect within the red blood cells themselves. Intrinsic hemolytic anemias are often inherited, such as sickle cell anemia and thalassemia. These conditions produce red blood cells that do not live as long as normal red blood cells.Extrinsic: Red blood cells are produced healthy but are later destroyed by becoming trapped in the spleen, destroyed by infection, or destroyed from drugs that can affect red blood cells. In severe cases the destruction takes place in the circulation. Possible causes of extrinsic hemolytic anemia include: Infections, such as hepatitis, cytomegalovirus (CMV), Epstein-Barr virus (EBV), typhoid fever, E. coli (escherichia coli), mycoplasma pneumonia, or streptococcus Medications, such as penicillin, antimalaria medications, sulfa medications, or acetaminophen Leukemia or lymphoma Autoimmune disorders, such as systemic lupus erythematous (SLE, or lupus), rheumatoid arthritis, Wiskott-Aldrich syndrome, or ulcerative colitis Various tumors Hypersplenism Mechanical heart valves that may shear red blood cells as they leave the heart Autoimmune hemolytic anemia, in which the body's immune system creates an antibody against its own blood cells Some types of extrinsic hemolytic anemia are temporary and resolve over several months. Other types can become chronic with periods of remissions and recurrence.


reference: national Cancer Institute – Glossary for Registrars

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